![]() ![]() Metabolic profiling studies have commonly noted increased free fatty acids and other lipid species in the plasma or serum of subjects with NAFLD. Thus, comprehensive metabolic profiling holds potential for identifying specific disease-related patterns and non-invasive biomarkers The metabolic abnormalities related to fatty liver are reflected in the level of circulating metabolites. Therefore, metabolic perturbations contributing to the development of the disease should be identified before clinical manifestations occur. In the early phase, NAFLD is asymptomatic, benign and often reversible, but if not controlled, it may progress to non-alcoholic steatohepatitis (NASH), cirrhosis and ultimately liver failure. The prevalence of non-alcoholic fatty liver (NAFLD) is on the rise, currently affecting up to 30% of the adult population and an increasing number of children in the developed countries. Isoleucine, leucine, valine, phenylalanine, tyrosine and orosomucoid Factor 3,Īcetate, alanine, lactate, pyruvate Factor 4,Įsterified cholesterol, free cholesterol, omega 6 fatty acids, phosphoglycerides, phosphocholines and sphingomyelines Factor 5,īeta-hydroxybutyrate, citrate, histidine Factor 6, Omega 7and 9 and saturated fatty acids, total fatty acids, mono-unsaturated fatty acids Factor 2, High-sensitivity C-reactive protein Factor 1, Homeostatic model assessment of insulin resistance TG, Non-esterified fatty acids HOMA-IR index, ![]() Participation in leisure time physical activity FM,Ībdominal subcutaneous adipose tissue VAT, Non-alcoholic fatty liver disease 1H MRS, 135038) Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013) China State Sport General Adiministration (No: 2013B040) and EVO research grants 2012/2013 from Oulu University Hospital.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: ArrayExpress data are available via the EMBL-EBI ( ).įunding: The study funding is supported by various sources: The academy of Finland SKID-KIDS program (No. Received: JAccepted: SeptemPublished: October 6, 2015Ĭopyright: © 2015 Cheng et al. PLoS ONE 10(10):Įditor: Patricia Aspichueta, University of Basque Country, SPAIN (2015) Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease. Citation: Cheng S, Wiklund P, Autio R, Borra R, Ojanen X, Xu L, et al. ![]()
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